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g.Management Replacement therapy with immunoglobulin G IgG administered intravenously IVIG or subcutaneously SCIG is the treatment of choice for most primary immunodeficiency syndromes including the following Xlinked agammaglobulinemia Bruton disease XLA CVID Severe combined immunodeficiency SCID HyperIgM ADA deficiency WiskottAldrich syndrome WAS Treatment of secondary hypogammaglobulinemia is directed at the underlying cause as follows IVIG is not indicated for lymphoproliferative disorders unless immunoglobulin levels are low in association with recurrent infections or if IVIG is being used for autoimmune conditions that may accompany these disorders Live vaccines should not be given to patients with Tcell disorders XLA or other severe Bcell disorders or to the family members of such patients High doses of IVIG or intrathecal immunoglobulin may be beneficial in patients with XLA who have enteroviral meningoencephalitis Hematopoietic stem cell transplantation HSCT is the treatment of choice for SCID and if a matched donor is available for ADA deficiency Enzyme replacement with polyethylene glycolADA PEGADA may be an effective alternative for patients with ADA deficiency who lack an HLAidentical sibling Tumor necrosis factor TNF inhibitors have been used to treat granulomatous diseases in patients with CVID Gene therapy has been shown to be successful in reconstituting immune function in infants with Xlinked SCID but efficacy is less proven in older children and young adults See Treatment and Medication for more detail.However the manner in which patients were accrued to this study probably biased its findings resulting in substantially higher effectiveness rates than are normally observed in clinical practice.
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PubMed Eardley I Wright P MacDonagh R Hole J Edwards A.However rats that were deprived of sleep live for only about three weeks.frequency signal at the Larmor frequency of rotation.
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